新产品编号:1561943
Chemical Name: 2-(6-Methoxy-3,4-dihydro-1-naphthyl)-4H-3,1-benzoxazin-4-one
项目整合开发状态: Preclinical
项目研究机构: Domp?(Originator)
合成路线:Condensation of of 2-iodoaniline (I) with vinyl triflate (II) in the presence of Pd(PPh3)4 and K2CO3 under atmosphere of CO produced the intermediate amide,which underwent an annellation reaction to the title benzoxazinone.
📌 参考资料/链接：
参考文献标题:Synthesis and in vitro and in vivo evaluation of the 2-(6'methoxy-3',4'-dihydro-1'-naphtyl)-4H-3,1-benzoxazin-4-one as a new potent substrate inhibitor of human leukocyte elastase
文献作者:Arcadi,A.; Asti,C.; Brandolini,L.; Caselli,G.; Marinelli,F.; Ruggieri,V.
参考来源:Bioorg Med Chem Lett 1999,9(9),1291