J-109404
Chemical Name: 1,11-Dihydroxy-12-(beta-D-glucopyranosyl)-6-[2-hydroxy-1-(hydroxymethyl)ethylamino]-12,13-dihydro-4cH-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,7aH)-dione
项目整合开发状态: Preclinical
项目研究机构: Banyu (Originator), Merck & Co. (Originator)
合成路线:The compound was prepared from the previously reported cyclic anhydride (I),upon condensation with 2-hydrazino-1,3-propanediol (II) in DMF at 80 C.
📌 参考资料/链接：
参考文献标题:Synthesis and biological activities of topoisomerase I inhibitors,6-N-amino analogues of NB-506
文献作者:Ohkubo,M.; Kojiri,K.; Kondo,H.; Tanaka,S.; Kawamoto,H.; Nishimura,T.; Nishimura,I.; Yoshinari,T.; Arakawa,H.; Suda,H.; Morishima,H.; Nishimura,S.
参考来源:Bioorg Med Chem Lett 1999,9(9),1219