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6,7-Dimethylesculetin, Scoparone

Chemical Name: 6,7-(Dimethoxy)-2H-1-benzopyran-2-one
项目整合开发状态: Not Determined
项目研究机构: Sigma-Aldrich (Supplier)
合成路线:Hydroquinone (I) is converted to 1,2,4-triacetoxybenzene (II),which is condensed with malic acid (A) to afford 6,7-dihydroxycoumarin (aesculetin) (III).This is methylated with dimethyl sulfate in acetone to give Scoparone.
📌 参考资料/链接:
参考文献标题:
文献作者:DuH,S.B.; Parihar,D.B.
参考来源:Proc Ind Acad Sci 1947,106(19,Suppl.2),153

📄 详细内容


合成路线:Hydroquinone (I) is converted to 1,2,4-triacetoxybenzene (II),which is condensed with malic acid (A) to afford 6,7-dihydroxycoumarin (aesculetin) (III).This is methylated with dimethyl sulfate in acetone to give Scoparone.

参考文献标题:
文献作者:Singh,G.B.; et al.
参考来源:J Sci Ind Res 1956,15(19,Suppl.2),190-193


合成路线:Hydroquinone (I) is converted to 1,2,4-triacetoxybenzene (II),which is condensed with malic acid (A) to afford 6,7-dihydroxycoumarin (aesculetin) (III).This is methylated with dimethyl sulfate in acetone to give Scoparone.

参考文献标题:
文献作者:Thakur,R.S.; et al.
参考来源:Res and Ind 1975,3(19,Suppl.2),129-131


合成路线:Hydroquinone (I) is converted to 1,2,4-triacetoxybenzene (II),which is condensed with malic acid (A) to afford 6,7-dihydroxycoumarin (aesculetin) (III).This is methylated with dimethyl sulfate in acetone to give Scoparone.

参考文献标题:
文献作者:Stefanovic,M.; et al.
参考来源:Phytochem 1973,12(19,Suppl.2),2996


合成路线:Hydroquinone (I) is converted to 1,2,4-triacetoxybenzene (II),which is condensed with malic acid (A) to afford 6,7-dihydroxycoumarin (aesculetin) (III).This is methylated with dimethyl sulfate in acetone to give Scoparone.

参考文献标题:
文献作者:King,F.E.; et al.
参考来源:J Chem Soc 1954,106(19,Suppl.2),1392-99


合成路线:Hydroquinone (I) is converted to 1,2,4-triacetoxybenzene (II),which is condensed with malic acid (A) to afford 6,7-dihydroxycoumarin (aesculetin) (III).This is methylated with dimethyl sulfate in acetone to give Scoparone.
参考文献标题:Scoparone
文献作者:Arya,V.P.
参考来源:Drugs Fut 1978,3(7),550