新产品编号:1497081

Chemical Name: 3-Chloro-5,8-dimethoxy-3-(3-methoxyphenoxy)-1,4-naphthoquinone
项目整合开发状态: Biological Testing
项目研究机构: Memorial Sloan-Kettering Cancer Center (Originator)
合成路线:Friedel Crafts condensation of p-dimethoxybenzene (I) with dichloromaleic anhydride (II) in a molten mixture of AlCl3 and NaCl yielded dichloronaphthazarin (III).Finally,treatment of (III) with resorcinol (IV) and Na2CO3 in DMSO at room temperature furnished the target compound.

合成路线:Friedel Crafts condensation of p-dimethoxybenzene (I) with dichloromaleic anhydride (II) in a molten mixture of AlCl3 and NaCl yielded dichloronaphthazarin (III).Subsequent methylation of (III) with CH3I in the presence of Ag2O in CHCl3 gave a mixture of dimethoxy naphthoquinones (IV) and (V),from which the desired isomer (IV) was isolated by recrystallization from CHCl3-CCl4.Finally,treatment of (IV) with 3-methoxyphenol (VI) and Na2CO3 in DMSO at room temperature furnished the target compound.

合成路线:Friedel Crafts condensation of p-dimethoxybenzene (I) with dichloromaleic anhydride (II) in a molten mixture of AlCl3 and NaCl yielded dichloronaphthazarin (III).Subsequent methylation of (III) with CH3I in the presence of Ag2O in CHCl3 gave a mixture of dimethoxy naphthoquinones (IV) and (V),from which the desired isomer (IV) was isolated by recrystallization from CHCl3-CCl4.Finally,treatment of (IV) with 3,5-dimethoxyphenol (VI) and Na2CO3 in DMSO at room temperature furnished the target compound.