新产品编号:1459113
Chemical Name: N-[3-(4-Cyanobenzamido)-2,2-dimethylnonanoyl]-L-phenylalanine ethyl ester
项目整合开发状态: Biological Testing
项目研究机构: Nippon Steel (Originator)
合成路线:The condensation of ethyl isobutyrate (I) with ethanal and trimethylsilylamine in THF gives the azetidinone (III),which is treated with 4-cyanobenzoic acid succinimidyl ester (IV) in DMF yielding 3-(4-cyanobenzamido)-2,2-dimethylnonanoic acid (V).Finally,this compound is condensed with L-phenylalanine ethyl ester (VI) by means of DEC and HOBT in dichloromethane.
📌 参考资料/链接：
参考文献标题:N-[2,2-Dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: Structural requirements for potent inhibition of alpha-chymotrypsin
文献作者:Iijima,K.; Katada,J.; Yasuda,E.; Uno,I.; Hayashi,Y.
参考来源:J Med Chem 1999,42(2),312