新产品编号:1457531
Chemical Name: 2(S)-(6-Methoxynaphthalen-2-yl)propionic acid 2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)ethyl ester
项目整合开发状态: Biological Testing
项目研究机构: Alcon (Originator)
合成路线:The title compound was prepared by coupling of 2-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)ethanol (I) with (S)-naproxen (II) by means of DCC and HOBt in acetonitrile.
📌 参考资料/链接：
参考文献标题:Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants,5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products
文献作者:Hellberg,M.; Graff,G.; Gamache,D.A.; Nixon,J.C.; Garner,W.H.(Alcon Laboratories,Inc.)
参考来源:EP 0799219; JP 1998511663; WO 9620187
📄 详细内容
合成路线:The title compound was prepared by coupling of 2-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)ethanol (I) with (S)-naproxen (II) by means of DCC and HOBt in acetonitrile.
参考文献标题:Novel esters and amides of nonsteroidal antiinflammatory carboxylic acids as antioxidants and antiproliferative agents
文献作者:Hellberg,M.R.; Namil,A.; Delgado,P.; David,K.C.; Kessler,T.L.; Graff,G.; Haggard,K.S.; Nixon,J.C.
参考来源:J Med Chem 1999,42(2),267