新产品编号:1451203
Chemical Name: 3'-Deoxy-2',3'-didehydro-5'-O-[[O-(2-naphthylmethyl)-L-alanino](phenoxy)phosphoryl]thymidine
项目整合开发状态: Biological Testing
项目研究机构: Rega Institute for Medical Research (Originator)
合成路线:Title phosphoramidate was obtained by condensation of phenyl [(2-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
合成路线:Title phosphoramidate was obtained by condensation of phenyl (phenoxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
合成路线:Title phosphoramidate was obtained by condensation of phenyl (benzyloxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
合成路线:Title phosphoramidate was obtained by condensation of phenyl [(1-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
📌 参考资料/链接：
参考文献标题:Synthesis,anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T)
文献作者:McGuigan,C.; Sutton,P.W.; Cahard,D.; Turner,K.; O'Leary,G.; Wang,Y.; Gumbleton,M.; De Clercq,E.; Balzarini,J.
参考来源:Antivir Chem Chemother 1998,9(6),473