新产品编号:1446457

Chemical Name: 7-Methyl-5-methoxy-7H-pyrido[4,3-c]carbazole
项目整合开发状态: Biological Testing
项目研究机构: Biotech Research Laboratories (Originator)
合成路线:The reaction of 2-methoxy-9-methylcarbazole-3-carbaldehyde (I) with malonic acid gives the propenoic acid (III),which by treatment with sodium azide and ethyl chloroformate is converted into the azide (IV).The cyclization of (IV) in refluxing ortho-dichlorobenzene affords 5-methoxy-7-methyl-2,7-dihydro-1H-pyrido [4,3-c]carbazol-1-one (V),which by treatment with POCl3 is converted into the 1-chloro derivative (VI).Finally,this compound is dechlorinated by hydrogenation with H2 over Pd/C.