NSC-639830, IST-622

Chemical Name: 6-O-Ethoxypropionyl-3',4'-O-(exo-benzylidene)chartreusin; 10-[3,4-O-exo-Benzylidene-2-O-(alpha-D-digitalosyl)-beta-D-fucosyloxy]-6-(3-ethoxypropionyloxy)-1-methyl-5,12-dihydrobenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione; 10-[3,4-O-exo-Benzyli
项目整合开发状态: Discontinued
项目研究机构: Ishihara Sangyo (Originator), Mitsui Pharmaceuticals (Codevelopment)
合成路线:Ketalization of chartreusin (I) with benzaldehyde (II) using p-toluenesulfonic acid in the presence of molecular sieves,yielded the corresponding 3',4'-O-benzylidene derivative as a mixture of endo- and exo-isomers,which were separated by column chromatography.The required exo-isomer (III) was then esterified with 3-ethoxypropionic acid (IV) by means of DCC,producing the title ester.