BI-L-226

Chemical Name: 2,6-Dimethyl-4-[2-(2-thienyl)vinyl]phenol
项目整合开发状态: Biological Testing
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:The reaction of 2,6-di-tert-butyllphenol (I) with hexamethylenetetramine (HMT) and sulfuric acid in ethyleneglycol at 130 C gives 4-hydroxy-3,5-di-tert-butylbenzaldehyde (II),which is finally condensed with 2-(3-pyridyl)acetic acid (III) by means of piperidine in dichloromethane at 130 C.

合成路线:The reaction of 2,6-dimethylphenol (I) with hexamethylenetetramine (HMT) and sulfuric acid in ethyleneglycol at 130 C gives 4-hydroxy-3,5-dimethylbenzaldehyde (II),which is finally condensed with 2-(2-thienyl)acetic acid (III) by means of piperidine in dichloromethane at 130 C.

合成路线:The reaction of 2,6-dimethylphenol (I) with hexamethylenetetramine (HMT) and sulfuric acid in ethyleneglycol at 130 C gives 4-hydroxy-3,5-dimethylbenzaldehyde (II),which is finally condensed with 2-(4-fluorophenyl)acetic acid (III) by means of piperidine in dichloromethane at 130 C.