Methanandamide-(R), (R)-Methanandamide
Chemical Name: (all-Z)-N-[2-Hydroxy-1(R)-methylethyl]-5,8,11,14-icosatetraenamide
项目整合开发状态: Preclinical
项目研究机构: National Cancer Institute (Originator), University of Connecticut (Originator)
合成路线:Treatment of arachidonic acid (I) with oxalyl chloride in benzene containing DMF afforded acid chloride (II),which was then coupled to (R)-2-amino-1-propanol (III) in THF to yield the corresponding arachidonic acid amide.
📌 参考资料/链接：
参考文献标题:(R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability
文献作者:Abadji,V.; Lin,S.; Taha,G.; Griffin,G.; Stevenson,L.A.; Pertwee,R.G.; Makriyannis,A.
参考来源:J Med Chem 1994,37(12),1889