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新产品编号:1441711

Chemical Name: (all-Z)-N-(2-Propynyl)-5,8,11,14-icosatetraenamide
项目整合开发状态: Biological Testing
项目研究机构: National Hellenic Research Foundation (Originator), University of Connecticut (Originator)
合成路线:Title compound was prepared by formation of the arachidonic acid chloride (II) upon treatment of the corresponding acid (I) with oxalyl chloride in CH2Cl2 containing DMF at 0 C,followed by condensation with propargylamine (III).

合成路线:Title compound was prepared by formation of the arachidonic acid chloride (II) upon treatment of the corresponding acid (I) with oxalyl chloride in CH2Cl2 containing DMF at 0 C,followed by condensation with 2-chloroethylamine - HCl (III) in the presence of pyridine.
📌 参考资料/链接:
参考文献标题:Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability
文献作者:Lin,S.; Khanolkar,A.D.; Fan,P.; Goutopoulos,A.; Qin,C.; Papahadjis,D.; Makriyannis,A.
参考来源:J Med Chem 1998,41(27),5353