新产品编号:1436965

Chemical Name: trans-7-Bromo-2-methyl-4-oxo-2,3,4,10-tetrahydro-1H-phenothiazine-3-carboxylic acid tert-butyl ester
项目整合开发状态: Preclinical
项目研究机构: 3M Pharmaceuticals (Originator), Bristol-Myers Squibb (Originator)
合成路线:The reaction of 4-bromoaniline (I) with potassium thiocyanate and bromine in acetic acid gives the benzothiazole (III) through the intermediate (II).The hydrolysis of (III) with NaOH affords 4-bromo-2-sulfanylaniline (IV),which is cyclized with 4-hydroxy-6-methyl-2-oxo-3-cyclohexene-1-carboxylic acid tert-butyl ester (V) in refluxing toluene.