BAS-118
Chemical Name: N-Methyl-3-[2-(2-naphthyl)acetamido]benzamide
项目整合开发状态: Preclinical
项目研究机构: Mitsubishi Chemical (Originator)
合成路线:2-Naphthylacetic acid (I) was converted to the corresponding acid chloride (II) upon treatment with oxalyl chloride in the presence of a catalytic amount of DMF.Subsequent coupling of acid chloride (II) with N-methyl-3-aminobenzamide (III) in pyridine furnished the target diamide.
📌 参考资料/链接：
参考文献标题:Amide derivs.
文献作者:Ando,R.; Watanabe,K.; Chiba,N.; Kawamura,M.(Mitsubishi Chemical Corp.)
参考来源:EP 0887341; JP 1999071336
📄 详细内容
合成路线:2-Naphthylacetic acid (I) was converted to the corresponding acid chloride (II) upon treatment with oxalyl chloride in the presence of a catalytic amount of DMF.Subsequent coupling of acid chloride (II) with N-methyl-3-aminobenzamide (III) in pyridine furnished the target diamide.
参考文献标题:3-(Arylacetylamino)-N-methylbenzamides: New class of selective anti-Helicobacter pylori agents
文献作者:Ando,R.; et al.
参考来源:222nd ACS Natl Meet (Aug 26 2001,Chicago) 2001,Abst MEDI 248
合成路线:2-Naphthylacetic acid (I) was converted to the corresponding acid chloride (II) upon treatment with oxalyl chloride in the presence of a catalytic amount of DMF.Subsequent coupling of acid chloride (II) with N-methyl-3-aminobenzamide (III) in pyridine furnished the target diamide.
参考文献标题:3-(Arylacetylamino)-N-methylbenzamides: A novel class of selective anti-Helicobacter pylori agents
文献作者:Ando,R.; Kawamura,M.; Chiba,N.
参考来源:J Med Chem 2001,44(25),4468