新产品编号:1400579
Chemical Name: 4-[4-(4-Fluorophenyl)piperazin-1-ylcarbonyl]-3-methyl-1-oxaspiro[4.5]dec-3-en-2-one
项目整合开发状态: Biological Testing
项目研究机构: Universit?d'Auvergne-Clermont-Ferrand (Originator)
合成路线:The condensation between cyclohexanone (I) and dimethyl itaconate (II) in the presence of NaOMe in cold Et2O afforded the spirobutenolide (III) together with some hydrolyzed product (IV).A further hydrolytic treatment with aqueous NaOH provided acid (IV),which was then converted to acid chloride (V) by treatment with PCl5 in refluxing cyclohexane.Reaction of this acid chloride with N-(4-fluorophenyl)piperazine in CH2Cl2 at 0 C produced the title amide.
📌 参考资料/链接：
参考文献标题:Spirobutenolides substituted by arylpiperazinyl-carbonyl moieties.Synthesis and antinociceptive properties
文献作者:Bois,F.; et al.
参考来源:Arzneim-Forsch Drug Res 1998,48(12),1156
📄 详细内容
合成路线:The condensation between cyclohexanone (I) and dimethyl itaconate (II) in the presence of NaOMe in cold Et2O afforded the spirobutenolide (III) together with some hydrolyzed product (IV).A further hydrolytic treatment with aqueous NaOH provided acid (IV),which was then converted to acid chloride (V) by treatment with PCl5 in refluxing cyclohexane.Reaction of this acid chloride with N-(2-methoxyphenyl)piperazine in CH2Cl2 at 0 C produced the title amide.
合成路线:The condensation between cyclohexanone (I) and dimethyl itaconate (II) in the presence of NaOMe in cold Et2O afforded the spirobutenolide (III) together with some hydrolyzed product (IV).A further hydrolytic treatment with aqueous NaOH provided acid (IV),which was then converted to acid chloride (V) by treatment with PCl5 in refluxing cyclohexane.Reaction of this acid chloride with N-(4-fluorophenyl)piperazine in CH2Cl2 at 0 C produced the title amide.
参考文献标题:Synthesis of acetylenic spirobutenolide derivatives and evaluation of their growth inhibitory effect on cells in culture
文献作者:Bador,P.; et al.
参考来源:Arzneim-Forsch Drug Res 1990,40(II)(10),1135-1139