新产品编号:1372103
Chemical Name: (Z)-2-[5-(1-Methoxynaphthalen-2-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
项目整合开发状态: Biological Testing
项目研究机构: CNRS (Originator)
合成路线:1-Methoxynaphthalene (I) was lithiated with n-butyllithium and subsequently treated with N-methylformanilide (II) to give the 2-naphthaldehyde (III).The Knoevenagel condensation of (III) with the rhodanineacetic acid (IV) in the presence of NaOAc in AcOH provided the target 5-(alkylidene)thiazolidine.
📌 参考资料/链接：
参考文献标题:Synthesis,activity,and molecular modeling of new 2,4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors
文献作者:Fresneau,P.; Cussac,M.; Morand,J.M.; Szymonski,B.; Tranqui,D.; Leclerc,G.
参考来源:J Med Chem 1998,41(24),4706