新产品编号:1365775

Chemical Name: (6R,8R,9R)-N-[4-Amino-9-(tert-butyldimethylsilyloxy)-6-(tert-butyldimethylsilyloxymethyl)-1,7-dioxa-2-thiaspiro[4.4]-3-nonen-8-yl]-N'-(2-methylpropenoyl)urea S,S-dioxide
项目整合开发状态: Biological Testing
项目研究机构: CSIC (Originator), Rega Institute for Medical Research (Originator)
合成路线:The reduction of azide (I) with trimethylphosphine in THF gives the amine (II),which is then treated with methacryloyl isocyanate (III) in acetonitrile yielding a mixture of alpha and beta phenylureas which is separated by centrifugal circular thin layer chromatography.

合成路线:The reduction of azide (I) with trimethylphosphine in THF gives the amine (II),which is treated with chlorosulfonyl isocyanate (A) in acetonitrile yielding the urea derivative (III).Finally,this compound is acetylated with acetic anhydride in pyridine to afford a mixture of alpha and beta acetylureas which is separated by centrifugal circular thin layer chromatography.

合成路线:The reduction of azide (I) with trimethylphosphine in THF gives the amine (II),which is then treated with phenyl isocyanate (A) in acetonitrile yielding a mixture of alpha and beta phenylureas which is separated by centrifugal circular thin layer chromatography.