新产品编号:1364193

Chemical Name: 3-[3-(Benzothiazol-6-yl)ureido]-1-[3-(3-isopropylureido)benzyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one
项目整合开发状态: Biological Testing
项目研究机构: Shionogi (Originator)
合成路线:Treatment of 3-aminobenzyl alcohol (I) with isopropyl isocyanate produced urea (II).Mesylation of alcohol (III),followed by reaction with LiBr gave benzyl bromide (III).Then,alkylation of 3-azidobenzazepine (IV) with (III) under phase-transfer conditions afforded (V).The azido group of (V) was reduced to amine (VI) by catalytic hydrogenation over Pd/C.Subsequent treatment of (VI) with carbonyl diimidazole produced isocyanate (VII).This was finally converted to the target compound by condensation with 6-aminobenzothiazole (VIII).