Thionisoxetine-(R), (R)-Thionisoxetine, LY-368975

Chemical Name: (R)-N-Methyl-3-[2-(methylsulfanyl)phenoxy]-3-phenylpropylamine hydrochloride
项目整合开发状态: Preclinical
项目研究机构: Lilly (Originator)
合成路线:Reduction of 3-chloropropiophenone (I) with NaBH4 produced 3-chloro-1-phenyl-1-propanol (II).Subsequent Mitsunobu coupling of (II) with 2-(methylthio)phenol (III) in the presence of DEAD and PPh3 afforded ether (IV).Finally,substitution of the halogen of (IV) for methylamine provided the corresponding secondary amine.