KNI-685

Chemical Name: 3'-Azido-5'-O-[3-[N-[1(S)-benzyl-2(S)-[4(R)-(N-tert-butylcarbamoyl)-5,5-dimethylthiazolidin-3-ylcarbonyl]-2-hydroxyethyl]carbamoyl]-2-methylbutyryl]-3'-deoxythymidine
项目整合开发状态: Biological Testing
项目研究机构: Kyoto Pharmaceutical University (Originator)
合成路线:The condensation of amine (I) with 2,2-dimethylsuccinic anhydride (II) afforded amide (III).This was then coupled with azidothymidine (IV) using DCC and DMAP to furnish the title compound.

合成路线:The condensation of azidothymidine (I) with 2,3-dimethylsuccinic anhydride (II) afforded amide (III).This was then coupled with amine (IV) using DCC and HOBt to furnish the title compound.