新产品编号:1354701

Chemical Name: Benzoyl-L-asparaginyl-L-(4-benzoyl)phenylalanyl-L-threoninamide
项目整合开发状态: Biological Testing
项目研究机构: University of Michigan (Originator)
合成路线:Coupling of N-Boc-benzoylphenylalanine (I) with threoninamide (II) using 1-(dimethylaminopropyl)-3-ethylcarbodiimide-HCl (EDC) and 1-hydroxybenzotriazole (HOBt) in the presence of N-methylmorpholine (NMM) afforded the N-Boc-dipeptide (III),which was deprotected with trifluoroacetic acid in CH2Cl2 to give (IV).Further coupling of (IV) with N-Boc-asparagine (V) using EDC and HOBt,followed by Boc deprotection with trifluoroacetic acid,provided tripeptide (VII).Finally,acylation of (VII) with benzoic anhydride in the presence of triethylamine furnished the target benzamide.