新产品编号:1343627

Chemical Name: 4-[2-[4-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(4-methylphenyl)propoxy]benzamido]phenoxy]butanoic acid
项目整合开发状态: Biological Testing
项目研究机构: Zeria (Originator)
合成路线:Reduction of ketoester (I) with NaBH4 in THF-MeOH afforded diol (II),which was treated with HCl in toluene to give chlorohydrin (III).Benzanilide (VII) was prepared by condensation of acid chloride (IV) with aniline (V),followed by catalytic hydrogenolysis of the resulting benzyl ether (VI).Then,alkylation of phenol (VII) with chloride (III) in the presence of K2CO3 provided ether (VIII).The hydroxyl group of (VIII) was converted to bromide (IX) using CBr4 and this compound was condensed with N-(2-methoxyphenyl)piperazine (X) to produce disubstituted piperazine (XI).The ethyl ester group of (XI) was finally hydrolyzed using KOH in aqueous EtOH.