T-506
Chemical Name: 2'-Deoxy-5-fluoro-3'-oleoyluridine 5'-[2-(trimethylammonio)ethyl]phosphate hydrate
项目整合开发状态: Phase II
项目研究机构: Toyama (Originator)
合成路线:The reaction of 2'-deoxy-5-fluoro-3'-O-oleoyluridine (I) with 2-bromoethylphosphodichloridate (II) by means of lutidine in THF gives 2'-deoxy-5-fluoro-3'-O-oleoyluridine 5'-(2-bromoethyl)phosphate (III),which is then condensed with trimethylamine (IV) in toluene.
📌 参考资料/链接：
参考文献标题:Novel 5-fluro-2'-desoxyuridine derivs.and their salts,process for theirpreparation and antitumor compsns.containing them
文献作者:Hori,T.; Myokan,I.; Miyabara,S.(Toyama Chemical Co.,Ltd.)
参考来源:CH 670091; DE 3535766; FR 2571374; GB 2166740; JP 1986091196; JP 1986171498; US 4684631; US 4740503
📄 详细内容
合成路线:The reaction of 2'-deoxy-5-fluoro-3'-O-oleoyluridine (I) with 2-bromoethylphosphodichloridate (II) by means of lutidine in THF gives 2'-deoxy-5-fluoro-3'-O-oleoyluridine 5'-(2-bromoethyl)phosphate (III),which is then condensed with trimethylamine (IV) in toluene.
参考文献标题:T-506
文献作者:Hoshi,A.; Prous,J.; Casta馿r,J.
参考来源:Drugs Fut 1990,15(5),467