QM-96625
Chemical Name: 2-Benzyl-4-(2-chlorobenzyl)-3,4-dihydro-2H-thieno[3,4-e]-1,2,4-thiadiazin-3-one 1,1-dioxide
项目整合开发状态: Biological Testing
项目研究机构: CSIC (Originator), Katholieke Universiteit Leuven (Originator)
合成路线:Alkylation of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (I) at the N-2 with benzyl chloride (II) in the presence of NaH in DMF yielded the 2-benzyl derivative (III),which was further alkylated with 2-chlorobenzyl chloride (IV) at the N-4 to provide the title compound.
合成路线:Alkylation of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (I) at the N-2 with 3-chlorobenzyl chloride (II) in the presence of NaH in DMF yielded the 2-benzyl derivative (III),which was further alkylated with chloroacetonitrile (IV) at the N-4 to provide the title compound.
合成路线:Alkylation of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (I) at the N-2 with 3-fluorobenzyl chloride (II) in the presence of NaH in DMF yielded the 2-benzyl derivative (III),which was further alkylated with chloroacetonitrile (IV) at the N-4 to provide the title compound.
📌 参考资料/链接：
参考文献标题:Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication
文献作者:Arranz,E.; D韆z,J.A.; Ingate,S.T.; Witvrouw,M.; Pannecouque,C.; Balzarini,J.; De Clercq,E.; Vega,S.
参考来源:J Med Chem 1998,41(21),4109