新产品编号:1326225

Chemical Name: [2R-(2alpha,3beta,4alpha,17abeta)]-4-Hydroxy-2-(hydroxymethyl)-3-methoxy-3,4,4a,11,12,17a-hexahydro-2H,10H-diindolo[1,2,3-de:3',2',1'-ij]pyrano[2,3-b]pyrrolo[3,4-g]quinoxaline-10,12-dione
项目整合开发状态: Biological Testing
项目研究机构: Aventis Pharma (Originator), INSERM (Originator), Novartis (Originator)
合成路线:Treatment of rebeccamycin (I) with p-toluenesulfonyl chloride and K2CO3 in refluxing THF yielded the 2'-tosylate (II).Further reaction of (II) with sodium azide in DMF at 70 C produced a 3:1 mixture of the cyclization product (III) and the azide (IV),which were separated by chromatography.Hydrogenolysis of (III) using ammonium formate and Pd/C in methanol provided the target dechlorinated compound.