新产品编号:1311987

Chemical Name: (1R,3R)-1-(2,6-Difluorophenyl)-3-methyl-3H-1,3-thiazolo[3,4-a]benzimidazole
项目整合开发状态: Biological Testing
项目研究机构: Katholieke Universiteit Leuven (Originator), Universit?degli Studi di Messina (Originator)
合成路线:The cyclization of a mixture of phenylene-1,2-diamine (I),2-sulfanylpropionic acid (II) and 2,6-difluorobenzaldehyde (III) in refluxing benzene gives a mixture of the two diastereomers of 1-(2,6-difluorophenyl)-3-methyl-1H,3H-thiazolo[3,4-a]benzimidazole,from which the trans-(racemic)-(IV) isomer has been isolated by silica gel column chromatography.The enantiomeric resolution has been performed by chiral HPLC affording the (1R,3R)-(IV) isomer,the target compound.