新产品编号:1308823
Chemical Name: (2R,3R,4R,5R)-2,5-Di(benzyloxy)-3,4-dihydroxy-N,N'-bis[2(R)-hydroxyindan-1(S)-yl]hexanediamide
项目整合开发状态: Biological Testing
项目研究机构: Link鰌ing University (Originator), Stockholm University (Originator), Uppsala University (Originator)
合成路线:Oxidation of L-mannonic gamma-lactone (I) with aqueous nitric acid provided bislactone (II).Subsequent treatment of bislactone (II) with benzyl trichloroacetimidate (III) and trifluoromethanesulfonic acid furnished dibenzyl ether (IV).Then,nucleophilic opening of both lactone groups of (IV) with (1S,2R)-1-amino-2-indanol (V) in refluxing dichloromethane yielded the title bisamide.
📌 参考资料/链接：
参考文献标题:Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors.Use of L-mannaric acid as a peptidomimetic scaffold
文献作者:Alterman,M.; Bj鰎sne,M.; M黨lman,A.; Classon,B.; Kvarnstrom,I.; Danielson,H.U.; Markgren,P.O.; Nillroth,U.; Unge,T.; Hallberg,A.; Samuelsson,B.
参考来源:J Med Chem 1998,41(20),3782