ENC-41-HP

Chemical Name: 1-Cyclopropyl-7-[4-(2,2-diphosphonoethyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
项目整合开发状态: Biological Testing
项目研究机构: ElizaNor Biopharmaceuticals (Originator)
合成路线:The title compound was synthesized by condensation of cyprofloxacin (I) with tetraethyl ethenylidenebisphosphonate (II) in the presence of Et3N in CH2Cl2

合成路线:The condensation of 1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid (I) with methylenediphosphonic acid tetraethyl ester (II) by means of TEA gives the addition product (III),which is finally hydrolyzed with trimethylsilyl bromide and water to afford the target diphosphonic acid.