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新产品编号:1283511

Chemical Name: N-(5-Bromo-2-pyridyl)-N'-[2-(1-piperidinyl)ethyl]thiourea
项目整合开发状态: Biological Testing
项目研究机构: Parker Hughes Institute (Originator)
合成路线:Condensation of 2-amino-5-bromopyridine (I) with 1,1-thiocarbonyl diimidazole (II) furnished the thiocarbonyl derivative (III).Further reaction of (III) with 1-(2-aminoethyl)piperidine (IV) gave the target thiourea.

合成路线:Condensation of 2-amino-5-bromopyridine (I) with 1,1-thiocarbonyl diimidazole (II) furnished the thiocarbonyl derivative (III).Further reaction of (III) with 1-(2-aminoethyl)piperazine (IV) gave the target thiourea.
📌 参考资料/链接:
参考文献标题:Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase
文献作者:Mao,C.; Vig,R.; Venkatachalam,T.K.; Sudbeck,E.A.; Uckun,F.M.
参考来源:Bioorg Med Chem Lett 1998,8(16),2213