新产品编号:1221813
Chemical Name:
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合成路线:Coupling of isovanillin (I) with 3-hydroxytetrahyrofuran (II) in the presence of triphenyl phosphine and diisopropyl azodicarboxylate yielded the tetrahydrofuryl ether (III).Subsequent oxidation of the aldehyde using sodium chlorite and sulfamic acid gave carboxylic acid (IV),which was further converted to acid chloride (V) upon treatment with SOCl2 in toluene.Finally,condensation of (V) with 4-amino-3,5-dimethylisoxazole (VI) provided the title compound.
📌 参考资料/链接：
参考文献标题:Novel 1,2,4-Triaminobenzene derivs.and process for their preparation
文献作者:Dieter,H.-R.; Engel,J.; Kutscher,B.; Polymeropoulos,E.; Szelenyi,S.; Nickel,B.(Asta Medica AG)
参考来源:DE 4200259; EP 0554543; JP 1993345752; US 5384330
📄 详细内容
合成路线:Coupling of isovanillin (I) with 3-hydroxytetrahyrofuran (II) in the presence of triphenyl phosphine and diisopropyl azodicarboxylate yielded the tetrahydrofuryl ether (III).Subsequent oxidation of the aldehyde using sodium chlorite and sulfamic acid gave carboxylic acid (IV),which was further converted to acid chloride (V) upon treatment with SOCl2 in toluene.Finally,condensation of (V) with 4-amino-3,5-dimethylisoxazole (VI) provided the title compound.
参考文献标题:Substd.aromatic cpds.as cAMP phosphodiesterase- and TNF-inhibitors
文献作者:Fenton,G.; Palfreyman,M.N.; Thurairatnam,S.(Aventis Pharma SA)
参考来源:EP 0741707; JP 1997509654; WO 9520578
合成路线:Coupling of isovanillin (I) with 3-hydroxytetrahyrofuran (II) in the presence of triphenyl phosphine and diisopropyl azodicarboxylate yielded the tetrahydrofuryl ether (III).Subsequent oxidation of the aldehyde using sodium chlorite and sulfamic acid gave carboxylic acid (IV),which was further converted to acid chloride (V) upon treatment with SOCl2 in toluene.Finally,condensation of (V) with 4-amino-3,5-dimethylisoxazole (VI) provided the title compound.
参考文献标题:D-23129
文献作者:Tober,C.; Rundfeldt,C.; Rostock,A.; Bartsch,R.; Nickel,B.; Szeleny,I.; Herbst,M.; Dieter,R.; Olbrich,A.; Kutscher,B.; Sauer,W.; Jainta,H.; Jahn,W.; Engel,J.
参考来源:Drugs Fut 1995,20(11),1112