新产品编号:1220231

Chemical Name:
项目整合开发状态: Phase II
项目研究机构:
合成路线:Addition of methylmagnesium iodide to nitrile (I),followed by hydrolytic treatment,provided ketone (II),which was brominated in CHCl3-MeOH to give bromomethyl ketone (III).Alkylation of thiourea (V) with 3-(dimethylamino)propyl chloride (IV) produced S-alkyl isothiourea (VI).After hydrolysis of (VI) with NaOEt,the intermediate thiol (VII) was condensed with bromoketone (III) to yield the required thioether,which was finally converted to the citrate salt.