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新产品编号:1218649

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合成路线:Title compound was prepared by reductive alkylation of 3-phenylpropylamine (I) with 3'-methoxyacetophenone (II) using NaCNBH3 in the presence of titanium isopropoxide in EtOH.Subsequent chiral resolution of the resulting secondary amine (III) by chromatography on ChiralCel OD provided the desired R-enantiomer.
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参考文献标题:Calcium receptor active molecules
文献作者:Nemeth,E.F.; Van Wagenen,B.C.; Balandrin,M.F.(NPS Pharmaceuticals,Inc.)
参考来源:WO 9304373