新产品编号:1209157
Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:Amine (I) was alkylated with 4-nitrophenethyl bromide (II) in refluxing isopropanol to yield the tertiary amine (III).Hydrogenation of the nitro group of (III) employing Pd/C afforded aniline (IV).Subsequent condensation of (IV) with methanesulfonyl chloride in the presence of Et3N produced the corresponding sulfonamide.The title compound was finally isolated as the hydrochloride salt.
📌 参考资料/链接:
参考文献标题:Novel antiarrhythmic cpds.
文献作者:Berzsenyi,P.; Druga,A.; P醫falusi,M.; Varga,I.; Rettegi,T.; Barlocco,D.; Moravcsik,I.; M醫yus,P.; Papp,G.; Varr? A.; Cignarella,G.; Simay,A.(Albert Szent-Gy鰎gyi Medical University ; Gyogyszerkutato Intezet Kft.)
参考来源:WO 9929655