新产品编号:1207575

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:2'-Deoxyadenosine (I) was protected as the diacetate (II) on treatment with acetic anhydride and a catalytic amount of dimethylaminopyridine.Then,reaction with an excess of isopentyl nitrite and diiodomethane under illumination of a tungsten lamp provided iodide (III).Subsequent treatment with ethanolic methylamine effected both deacetylation and substitution of iodide to give 2'-deoxy-N6-methyladenosine (IV).Finally,this was treated with phosphoryl chloride and Proton Sponge(R) in trimethyl phosphate at 0 C,followed by quenching with triethyl ammonium bicarbonate buffer to yield the target bisphosphate.