新产品编号:1202829
Chemical Name:
项目整合开发状态: Preclinical
项目研究机构: St. Marianna University School Med. (Originator)
合成路线:Condensation of trimethylhydroquinone (I) with 4-chloro-1-butanol (II) in the presence of phosphomolybdic acid in refluxing toluene yielded the chlorobutyl ether (III).Benzhydrylpiperazine (VI),(prepared from chlorodiphenylmethane (IV) and piperazine (V)),was then condensed with chloride (III) to give the target compound,which was isolated as the dihydrochloride salt.
📌 参考资料/链接:
参考文献标题:Synthesis of trimethylhydroquinone derivatives as anti-allergic agents with anti-oxidative actions
文献作者:Kawasaki,N.; Miyataka,H.; Nishiki,M.; Matsumoto,H.; Inagaki,N.; Nagai,H.; Satoh,T.
参考来源:Chem Pharm Bull 1999,47(2),177