新产品编号:1201247
Chemical Name:
项目整合开发状态: Biological Testing
项目研究机构: China Medical College (Originator), National Cancer Institute (Originator), University of North Carolina (Originator)
合成路线:The compound was prepared by condensation of acetophenone (I) with 3-flourobenzaldehyde (II) in refluxing ethanolic NaOH,followed by cyclization of the intermediate chalcone in diphenyl ether at 180 C.
合成路线:The desired 2'-amino chalcone is synthesized by a base-catalyzed condensation of 2-amino acetophenone (I) and benzaldehyde (II) by means of aqueous NaOH in EtOH.
📌 参考资料/链接：
参考文献标题:Antitumor agents.181.Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents
文献作者:Xia,Y.; Yang,Z.Y..; Xia,P.; Bastow,K.F.; Tachibana,Y.; Kuo,S.C.; Hamel,E.; Hackl,T.; Lee,K.H.
参考来源:J Med Chem 1998,41(7),1155