新产品编号:1196501
Chemical Name:
项目整合开发状态: Biological Testing
项目研究机构: National Institutes of Health (Originator), Rega Institute for Medical Research (Originator), University of Alberta (Originator), Wayne State University (Originator)
合成路线:Aldol condensation between 3,4-dichlorobenzaldehyde (I) and 4'-hydroxyacetophenone (II) in hydroalcoholic NaOH yielded chalcone (III).Then,Mannich reaction of (III) with N,N-dimethylmethyleneammonium chloride (IV) in refluxing acetonitrile provided the bis(dimethylamino) compound as the dihydrochloride.
📌 参考资料/链接：
参考文献标题:Cytotoxic activities of Mannich bases of chalcones and related compounds
文献作者:Dimmock,J.R.; Kandepu,N.M.; Hetherington,M.; Quail,J.W.; Pugazhenthi,U.; Sudom,A.M.; Chamankhah,M.; Rose,P.; Pass,E.; Allen,T.M.; Halleran,S.; Szydlowski,J.; Mutus,B.; Tannous,M.; Manavathu,E.K.; Myers,T.G.; De Clercq,E.; Balzarini,J.
参考来源:J Med Chem 1998,41(7),1014-1026