SM-20220

Chemical Name: N-(1-Methyl-1H-indol-2-ylcarbonyl)guanidine methanesulfonate
项目整合开发状态: Preclinical
项目研究机构: Sumitomo Pharmaceuticals (Originator)
合成路线:The methylaion of 4-methyl-1H-indole-2-carboxylic acid (I) with NaH and methyl iodide in DMF gives of 1,4-dimethylindole-2-carboxylic acid methyl ester (II),which is condensed with guanidine at 130 C,and treated with methanesulfonic acid in isopropanol.

合成路线:2-Indolecarboxylic acid (I) was esterified with MeOH and SOCl2 to provide methyl ester (II).Subsequent N-alkylation of (II) using methyl iodide and NaH afforded N-methyl indole (III).Guanidine,liberated by treatment of the hydrochloride salt with NaOMe,was finally condensed with indole ester (III) at 130 C to produce the corresponding acylguanidine,which was isolated as the mesylate salt.