PD-166309

Chemical Name: 3-[5-[4-(1,3-Benzodioxol-5-yl)-2-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3-ylmethyl]-2,3-dimethoxyphenoxy]propane-1-sulfonic acid sodium salt
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:Aldol condensation of piperonal (I) with 4-methoxyacetophenone (II) afforded chalcone (III).Subsequent addition of KCN to (III) in the presence of AcOH gave nitrile (IV),which was hydrolyzed in methanol in the presence of p-TsOH to provide ketoester (V).Subsequent base-catalyzed condensation of (V) with aldehyde (VI),followed by cyclization in refluxing AcOH furnished the target butenolide.