Chemical Name: (cis)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane
项目整合开发状态: Biological Testing
项目研究机构: National Cancer Institute (Originator), University of Pittsburgh (Originator)
合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
📄 详细内容
合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
参考文献标题:Synthesis and biological evaluation of a series of 1,1-dichloro-2,2,3-triaryl cyclopropanes as pure antiestrogens
文献作者:Day,B.W.; Magarian,R.A.; Jain,P.T.; Pento,J.T.; Mousissian,G.K.; Meyer,K.
参考来源:J Med Chem 1991,34(2),842-851
合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
参考文献标题:Synthesis and biological evaluation of basic side chain derivatives of Analog II as pure antiestrogens and antitumor agents
文献作者:Magarian,R.A.; et al.
参考来源:Anti-Cancer Drug Des 1995,10(4),311
合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
参考文献标题:Synthesis of cyclopropyl analogs of stilbenediol as possible antiestrogens
文献作者:Benjamin,E.J.; Magarian,R.A.
参考来源:J Pharm Sci 1975,641626-34
合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
参考文献标题:Synthesis and biological evaluation of gem-dichlorocyclopropyl and cyclopropyl analogs of stilbene congeners as potential antiestrogens
文献作者:Stobaugh,J.F.; Magarian,R.A.; Pento,J.T.
参考来源:J Pharmacol Sci 1982,711126-29
合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
参考文献标题:Synthesis of air and light sensitive cis-phenolic cyclopropane derivatives
文献作者:Afzal,J.; Pento,J.T.; Griffin,M.T.; Magarian,R.A.
参考来源:Synth Commun 1989,193061-68
合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
合成路线:By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
参考文献标题:Cyclopropyl antiestrogens: a new class of antitumor agents for the treatment of breast cancer
文献作者:Pento,J.T.
参考来源:Drugs Fut 1997,22(6),647