新产品编号:1145877

Chemical Name: 4-[4-(4-Benzylpiperidin-1-yl)-1-butynyl]phenol
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:4-Benzylpiperidine (I) was alkylated with butynyl tosylate (II) to afford the N-butynyl piperidine (III).Subsequent coupling of (III) with 4-iodophenol (IV) in the presence of Pd(PPh3)4 in pyrrolidine produced the corresponding butynyl phenol.

合成路线:4-Benzylpiperidine (I) was alkylated with propargyl tosylate (II) to afford the N-propynyl piperidine (III).Subsequent coupling of (III) with 4-iodophenol (IV) in the presence of Pd(PPh3)4 in pyrrolidine produced the corresponding propynyl phenol.