PD-157667

Chemical Name: 2-(4,4-Diphenylbutyl)-6-(perhydroazepin-1-yl)-1,2,3,4-tetrahydroisoquinolin-5-ol
项目整合开发状态: Biological Testing
项目研究机构: Neurex (Originator), Pfizer (Originator)
合成路线:Alkylation of 5-hydroxyisoquinoline (I) with bromide (II) in DMF at 80 C afforded isoquinolinium salt (III).This was reduced to tetrahydroisoquinoline (IV) by catalytic hydrogenation in the presence of Pd/C.Finally,Mannich reaction with formaldehyde and perhydroazepine (V) in THF-water at r.t.provided the target compound.