GW-250495

Chemical Name: 16alpha,17alpha-[(R)-Butylidenedioxy]-6alpha,9alpha-difluoro-11beta-hydroxy-3-oxo-4-androstene-17beta-carbothioic acid S-(2-oxotetrahydrofuran-3-y) ester
项目整合开发状态: Phase I
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Treatment of carboxylic acid (I) with diethyl chlorophosphate (II) in the presence of Et3N furnished the corresponding mixed anhydride (III).This was then condensed with the sodium salt of alpha-mercapto-gamma-butyrolactone (IV) to produce the title thioester.

合成路线:The title compound was prepared by condensation of the carbothioic acid (I) with alpha-bromo-gamma-butyrolactone (II) in the presence of K2CO3 in DMF.