PNU-167532

Chemical Name: 2-Benzyl-4-(3,4-difluorophenyl)-4-oxobutyric acid
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:Conjugate addition of benzylmagnesium chloride (II) to unsaturated ketone (I) in the presence of cuprous iodide-dimethyl sulfide complex afforded the 2-benzyl derivative (III).Then,the ester function was saponified with NaOH in MeOH to give the title acid.Resolution of the enantiomers was effected by fractional crystallization of the ephedrine salts.