新产品编号:1115819
Chemical Name: (6R,8aS)-6-Hydroxy-3-methoxy-11-(10-phthalimidodecyl)-5,6,9,10-tetrahydro-4aH-benzofuro[3a,3,2-ef][2]benzazepinium bromide
项目整合开发状态: Biological Testing
项目研究机构: SCRAS (Originator)
合成路线:Alkylation of potassium phthalimide (I) with an excess of 1,8-dibromooctane (II) in refluxing acetone afforded N-(8-bromooctyl)phthalimide (III).This was condensed with 6-O-demethylgalanthamine (IV) in the presence of Et3N in boiling acetonitrile to give phthalimidooctyl compound (V).Finally,reaction with N-bromosuccinimide in the presence of azobisisobutyronitrile provided the iminium bromide.
合成路线:Alkylation of potassium phthalimide (I) with an excess of 1,10-dibromodecane (II) in refluxing acetone afforded N-(10-bromodecyl)phthalimide (III).This was condensed with 6-O-demethylgalanthamine (IV) in the presence of Et3N in boiling acetonitrile to give phthalimidodecyl compound (V).Finally,reaction with N-bromosuccinimide in the presence of azobisisobutyronitrile provided the iminium bromide.
📌 参考资料/链接：
参考文献标题:Potent acetylcholinesterase inhibitors: Design,synthesis,and structure-activity relationships of bis-interacting ligands in the galanthamine series
文献作者:Mary,A.; Renko,D.Z.; Guillou,C.; Thal,C.
参考来源:Bioorg Med Chem 1998,6(10),1835