L-750667-[125I], [125I]-L-750667, L-750667
Chemical Name: 3-[4-(4-[125I]-Iodophenyl)piperazin-1-ylmethyl]-1H-pyrrolo[2,3-b]pyridine
项目整合开发状态: Biological Testing
项目研究机构: Merck Sharp & Dohme (Originator)
合成路线:L-750667 is prepared by condensation between 3-(dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine (I) and 1-(4-iodophenyl)piperazine (II) in refluxing toluene trough a gramine-type substitution of the dimethylamino group.
📌 参考资料/链接：
参考文献标题:Pyrrolo-pyridine derivs.
文献作者:Baker,R.; Curtis,N.R.; Kulagowski,J.J.; Leeson,P.D.; Ridgill,M.P.; Smith,A.L.(Merck Sharp & Dohme Ltd.)
参考来源:CA 2116213; EP 0623618; JP 1994279442; US 5432177; US 5622950; WO 9420497
📄 详细内容
合成路线:L-750667 is prepared by condensation between 3-(dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine (I) and 1-(4-iodophenyl)piperazine (II) in refluxing toluene trough a gramine-type substitution of the dimethylamino group.
参考文献标题:Pyrrolo-pyridine derivs.
文献作者:Baker,R.; Kulagowski,J.J.; Curtis,N.R.; Leeson,P.D.; Ridgill,M.P.; Smith,A.L.(Merck Sharp & Dohme Ltd.)
参考来源:US 5576319
合成路线:L-750667 is prepared by condensation between 3-(dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine (I) and 1-(4-iodophenyl)piperazine (II) in refluxing toluene trough a gramine-type substitution of the dimethylamino group.
参考文献标题:3-[[4-(4-Chlorophenyl)piperazin-1-yl]-methyl]-1H-pyrrolo[2,3-b]pyridine: An antagonist with high affinity and selectivity for the human dopamine D4 receptor
文献作者:Kulagowski,J.J.; Broughton,H.B.; Curtis,N.R.; Mawer,I.M.; Ridgill,M.P.; Baker,R.; Emms,F.; Freedman,S.B.; Marwood,R.; Patel,S.; Ragan,C.I.; Leeson,P.D.
参考来源:J Med Chem 1996,39(10),1941