新产品编号:1092089
Chemical Name: 20-(Hydroxyimino)-4,16-pregnadien-3-one
项目整合开发状态: Biological Testing
项目研究机构: University of Maryland (Originator)
合成路线:Title compound was obtained by Oppenauer oxidation of 3-beta-hydroxy-5,16-pregnadien-20-oxime (I),with subsequent migration of the double bond,using aluminum isopropoxide and cyclohexanone in toluene.
合成路线:Oppenauer oxidation of 3-beta-hydroxy-5,16-pregnadien-20-oxime (I),with subsequent migration of the double bond,using aluminum isopropoxide and cyclohexanone in toluene yielded conjugated ketone (II).Then,acetylation with Ac2O in pyridine provided the target oxime acetate.
📌 参考资料/链接:
参考文献标题:Synthesis and in vitro activity of some epimeric 20alpha-hydroxy,20-oxime and aziridine pregnene derivatives as inhibitors of human 17alpha-hydroxylase/C17,20-lyase and 5alpha-reductase
文献作者:Ling,Y.-Z.; Li,J.S.; Kato,K.; Liu,Y.; Wang,X.; Klus,G.T.; Marat,K.; Nnane,I.P.; Brodie,A.M.
参考来源:Bioorg Med Chem 1998,6(10),1683