SA-627
Chemical Name: N-(2-Bromo-4,6-dimethoxyphenyl)-N-ethyl-N-[6-methyl-4-(4-morpholinyl)-1,3,5-triazin-2-yl]amine methanesulfonate
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Treatment of cyanuric chloride (I) with methylmagnesium chloride afforded 2,4-dichloro-6-methyltriazine (II),which was condensed with aniline (III) to produce the anilinotriazine (IV).Subsequent displacement of the remaining chlorine atom of (IV) with morpholine (V) provided (VI).The target compound was then obtained by N-alkylation with iodoethane in the presence of NaH,followed by conversion to the methanesulfonate salt).
📌 参考资料/链接：
参考文献标题:Non-peptide corticotropin-releasing hormone antago
文献作者:Arvanitis,A.G.; Gilligan,P.J.; Chorvat,R.J.; Cheeseman,R.S.; Christos,T.E.; Bakthavatchalam,R.; Beck,J.P.; Cocuzza,A.J.; Hobbs,F.W.; Wilde,R.G.; Arnold,C.; Chidester,D.; Curry,M.; He,L.; Hollis,A.; Klaczkiewicz,J.; Krenitsky,P.J.; et al.
参考来源:J Med Chem 1999,42(5),805