SC-241
Chemical Name: 3-(2-Bromo-4-isopropylphenyl)-N,N-bis(2-methoxyethyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine-7-amine
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Condensation of 5-amino-4,6-dichloro-2-methylpyrimidine (I) and 2-bromo-4-isopropylaniline (II) in boiling ethoxyethanol gave diarylamine (III).Subsequent diazotization of (III) using NaNO2 and AcOH produced the triazolopyrimidine (IV),which was finally condensed with bis(2-methoxyethyl)amine (V) in the presence of Et3N in refluxing EtOH to provide the title compound.
📌 参考资料/链接：
参考文献标题:Synthesis,corticotropin-releasing factor receptor
文献作者:Chorvat,R.J.; Bakthavatchalam,R.; Beck,J.P.; Gilligan,P.J.; Wilde,R.G.; Cocuzza,A.J.; Hobbs,F.W.; Cheeseman,R.S.; Curry,M.; Rescinito,J.P.; Krenitsky,P.; Chidester,D.; Yarem,J.A.; Klaczkiewicz,J.D.; Hodge,C.N.; Aldrich,P.E.; et al.
参考来源:J Med Chem 1999,42(5),833