新产品编号:1082597

Chemical Name: 6,6,9,13,15,16-Hexamethyl-14-hydroxy-2,8-dioxabicyclo[10.4.0]hexadeca-12,14,16-trien-7-one; 5,5,8,11,13,14-Hexamethyl-12-hydroxy-3,4,5,6,9,10-hexahydro-2H,8H-1,7-benzodioxacyclododecin-6-one
项目整合开发状态: Biological Testing
项目研究机构: Alfa Wassermann (Originator)
合成路线:Arylpentanone (I),which was in equilibrium with its hemiacetal cyclic form,was alkylated with isopropyl 5-bromo-2,2-dimethyl-pentanoate (II) in the presence of NaH to afford ether (III).After saponification of the isopropyl and acetate esters of (III) with ethanolic KOH,the resulting ketoacid (IV) was reduced with NaBH4 to yield hydroxyacid (V).Finally,cyclization of (V) using 2,2'-dipyridyl disulfide,triphenylphosphine and silver perchlorate produced the target macrocyclic lactone.

合成路线:Arylbutanone (I),which was in equilibrium with its hemiacetal cyclic form,was alkylated with isopropyl 5-bromo-2,2-dimethyl-pentanoate (II) in the presence of NaH to afford ether (III).After saponification of the isopropyl and acetate esters of (III) with ethanolic KOH,the resulting ketoacid (IV) was reduced with NaBH4 to yield hydroxyacid (V).Finally,cyclization of (V) using 2,2'-dipyridyl disulfide,triphenylphosphine and silver perchlorate produced the target macrocyclic lactone.